From: Subject: FDA Public Health Advisory: Tegaserod maleate (marketed as Zelnorm) Date: Fri, 30 Mar 2007 16:06:36 -0400 MIME-Version: 1.0 Content-Type: multipart/related; type="text/html"; boundary="----=_NextPart_000_0000_01C772E5.64B18020" X-MimeOLE: Produced By Microsoft MimeOLE V6.00.2900.3028 This is a multi-part message in MIME format. ------=_NextPart_000_0000_01C772E5.64B18020 Content-Type: text/html; charset="Windows-1252" Content-Transfer-Encoding: quoted-printable Content-Location: http://www.fda.gov/cder/drug/advisory/tegaserod.htm FDA Public Health Advisory: Tegaserod maleate = (marketed as Zelnorm)
3D"FDA 3D"
3D"Center3D"U.S.3D"Center
 3D" 3D"HHS

FDA=20 Home Page | CDER Home = Page |=20 CDER Site=20 Info | Contact = CDER |=20 http://www.fda.gov/cder/wha= tsnew.htm

3D"
3D"CDER 3D"Drug
=
 
=20 =20 = 3D"Powered
 
3D"

FDA Public Health=20 Advisory
Tegaserod maleate (marketed as = Zelnorm)=20

FDA is issuing this public health advisory = to inform=20 patients and health care professionals that the sponsor of = Zelnorm=20 (tegaserod maleate), Novartis Pharmaceuticals Corporation, = has=20 agreed to stop selling Zelnorm.  Zelnorm is being taken = off the=20 market because a new safety analysis has found a higher = chance of=20 heart attack, stroke, and worsening heart chest pain that = can become=20 a heart attack in patients treated with Zelnorm compared to = those=20 treated with a sugar pill they thought was Zelnorm.

FDA announces the following, effective immediately:  =

  • At FDA=92s request, Novartis Pharmaceuticals = Corporation has=20 agreed to stop selling Zelnorm.=20
  • Patients being treated with Zelnorm should contact = their=20 physician to discuss alternative treatments for their = condition.=20
  • Patients who are taking Zelnorm should seek emergency = medical=20 care right away if they experience severe chest pain, = shortness of=20 breath, dizziness, sudden onset of weakness or difficulty = walking=20 or talking or other symptoms of a heart attack or = stroke. =20
  • Physicians who prescribe Zelnorm should work with = their=20 patients and transition them to other therapies as = appropriate to=20 their symptoms and need.

Zelnorm is a prescription medication approved for short = term=20 treatment of women with irritable bowel syndrome with = constipation=20 and for patients younger than 65 years with chronic=20 constipation.   In late February and early March = 2007,=20 Novartis Pharmaceuticals gave FDA the results of new = analyses of 29=20 clinical studies of Zelnorm for treatment of a variety of=20 gastrointestinal tract conditions; the data from all the = studies=20 were combined to assess the chance of side effects on the = heart and=20 blood vessels.  In each study, patients were assigned = at random=20 to either Zelnorm or a sugar pill they thought was = Zelnorm. =20 These 29 studies included 11,614 patients treated with = Zelnorm and=20 7,031 treated with a sugar pill.  The average age of = patients=20 in these studies was 43 years and most patients=9788%--were=20 women. 

The number of patients who suffered a heart attack, = stroke or=20 severe heart chest pain that can turn into a heart attack = was=20 small.  However, patients treated with Zelnorm had a = higher=20 chance of having any of these serious and life-threatening = side=20 effects than did those who were treated with a sugar = pill. =20 Thirteen patients treated with Zelnorm (0.1%) had serious = and=20 life-threatening cardiovascular side effects; among these, = four=20 patients had a heart attack (one died), six had a type of = severe=20 heart chest pain which can quickly turn into a heart attack, = and=20 three had a stroke.  Among the patients taking the = sugar pill,=20 only one (or 0.01%) had symptoms suggesting the beginning of = a=20 stroke that went away without complication.

There may be patients for whom no other treatment options = are=20 available and in whom the benefits of Zelnorm treatment = outweigh the=20 chance of serious side effects.  FDA will work with = Novartis to=20 allow access to Zelnorm for those patients through a special = program.

FDA has also indicated to Novartis a willingness to = consider=20 limited re-introduction of Zelnorm at a later date if a = population=20 of patients can be identified in whom the benefits of the = drug=20 outweigh the risks.  However, before FDA makes a = decision about=20 limited re-introduction, any proposed plan would be = discussed at a=20 public advisory committee meeting. 

 

3D"to Back=20 to Top     3D"back Back=20 to Tegaserod meleate

3D"PDF = PDF=20 requires the free Adobe=20 Acrobat Reader

Date created: March 30, 2007

3D"
3D"
3D"horizonal

CDER=20 Home Page | CDER Site = Info |=20 Contact = CDER | http://www.fda.gov/cder/wha= tsnew.htm
FDA Home Page | = Search FDA Site = | FDA A-Z = Index |=20 Contact FDA = | Privacy | Accessibility | HHS Home Page

FDA/Center for Drug Evaluation and=20 Research
3D"
------=_NextPart_000_0000_01C772E5.64B18020 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.fda.gov/cder/templates/graphics/fda_mast_01.gif R0lGODlhdABGALMAAJmZzDMzZszM/2ZmmTMzmf////8AAMzMzAAAZgAAAAAAAAAAAAAAAAAAAAAA AAAAACwAAAAAdABGAAAE/9DISau9OOvNu/9gKI5kaZ5oqq5s675wLM90bd94ru98nyHAoHBILBqP yKRyyWw6n9CodEqtWq/YrHbL7Xq/4LB4TC6bp4SCes1uu98HQEAJcA/O1fR7z3cfCEd6BQN1anN4 UoJ9i3x3RQJqBwgBawCIiZEEmpucnZ6cAJCVRANrBAADpWqAl096B6qMfAIABLGDQ5V6AaKSrU6v t7J8tWysCIUFAQdqxWqOv0vBw7J/a76CqcbMatFM0wW1n+OgbLCmCNzKbQeUzd5K4NBRyQOiqGuE dsnH8EXyVbidK6Cu3TVR6yL5CxRJlYADECNCrDWRwERSptxYXBMglrZnC///NVxkjeCrIhnZOAsH RB0vNQJCEgHHp6TNItwUKUN4SBA+kDKDvLKVqqjRVEMVEhGl6COuIPxcBgUy9KjVAUkJEnFXQBHX AkTWCPA5FQHNPTZPDikkwGM9jM/4TT0LJ6uvIG4jcY35iKPYuSMLPJQY0dlNIAGSdTWlbp4Qnx6D AjSSleABhKu4rfxDWKIxhJIDO36cqc8pjgg1VYsccrJIk3so5oslSWcjZncXup6pcJxiS2x6kvPU NTRBVaOFXutsB9kos52jFwZ8HOhrRm3NBqdKTRn1gcm5L8reMp/yYeG9dUSK9Mj6q1gP4S0q5D18 o2Xz69/Pv7///wAGKOBegAQWaOCBCCaYRXcMNujggxBGKOGEFFZomXQYZqjhhhx26OGHIIYo4ogk lmjiiSimqOKKLLbo4oswxijjjDTWaOONOOao44489ujjj0AGKeSQRBZp5JFIJqnkkkNGAAA7 ------=_NextPart_000_0000_01C772E5.64B18020 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.fda.gov/cder/templates/graphics/fda_mast_bkgrd.gif R0lGODlhFABGALMAAJmZzDMzZszM/2ZmmTMzmf////8AAMzMzAAAZgAAAAAAAAAAAAAAAAAAAAAA AAAAACwAAAAAFABGAAAETNDISau9OOvNu/9gKGZIaZ5oqq5s675wLM90bd94ru987//AoHBILBqP yKRyuSw4n9CodEqFHq7YrHbL7Xq/4LB4TC6bz+i0es1upyMAOw== ------=_NextPart_000_0000_01C772E5.64B18020 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.fda.gov/cder/templates/graphics/fda_cder_02.gif R0lGODlhfwFGALMAAP//////mf+Zmf8AAMzMzMzMmZmZmWaZmWZmmWYAMzMzZgAAZv//zP//Zv// M///ACwAAAAAfwFGAAAE/3DISau9OOvNu/9gKI5kaZ5oqq5s675wLM90bd94ru987//AoHBILBqP yKRyyWw6n9CodEqtWq/YrHbL7Xq/4LCYtyibz+i0es1uu9/wuHxOr9vv+Lx+z+/7/4CBgoOEhYaH iImKi4yNjo+QkZKTlJWWl5iZmpucnZ6foKGio6SlpqeaCAaQCgWofAoGCq+0tXixBQEBjQoIubu2 db66s8HGcgjJCMWhus6Nv7puCr3KzKlxBs4B17fdcd+R4YG/BebEZQi6vwhr2gUG0eNo2uvm587z furSvM9puLYFiCYrk7p2cfLt4adPTS5XlHStOsRP17IzrQIUdBgA4YJ6Hv/b9CLYqx63Qwr+NVJ5 xle0kwsyasSkbSKcXw1vWqSj0BGziomcQUSTctw7NDvjVGSWEmahpsBW9lsjFE25Sw/l4NzDjic6 OAZC6vFlBiiiqgCjppFIryOynmW05dwD9RHLteuIOrMpCercBVvHfpVzFE5KsXnMncnFtxBavWua ij34dnBMp4TqOrqLNG9by5AqIl4T+JO20XbUDZU6UE3KyJ7PuFUKtwzmmDmpvdGtefc4pvp0L+As O7YZqI2B3/lrxmRjosVK4z4OkLly166v8UPMNDsafqvLhFPG5rqbxxjVpk9KvfLtz+y/b3uebj5x jCYHMlVcsQDiYRLdZ5v/cWZE09IuMt2jWEwK8iWTfgkZ6BpBpR320V7iRTOZU6240l836mD0UgG9 CJVMcx72FItAs/SXzCwdEhWNf2moMwtB5xEonnrHbYMaHEsVyFReGYUHGITSHXlSRTye8c6NO5U4 EJOWgXSZgMPpeOFOACoZ4FSqqMTPKlTOc5gz/0UpD4MSvdQRVAoFdNKKUwoEDJ1RqTPRdnbuAh6c ZKJTzyp9GlDPatstMGZZ7LhJnxno9cjGS4++EeRlzPzSY2sFDmZcPcyYxAao9bm1TS4wolkWe2ZR paVo+cUj6l3/9PZLWPPEk+VM69nkF5yz5YfQoIpuM4udqe6U345qyVXs/2ynwlMOQ8xCBB6bsTVl U6JMwhMXlpHuWJ5AJArTk7PP8mXls6sReyWi911bKkKircpplqv1pka4z87EJDV50dqPu1tWWgaN h1plWU+3FjfblVEFdumWCGlWT3otJiVla2Oq1BREH9s7lHQMG1dbZ/em1waVD9NmT0+1ydvVpsCs y2yTSm6rsXEhp4tyG/xCBdFVH5UrMDAzsyvSknD13ClMSe96jUqBOf2sR/9EfVGiN7cTi6HZeuZ0 z/I2l1TUSTps5GXTuPmjGhWFtVWrNwMMmqq16etwqDun3HPUuwKtpdAHxzegelmzp7d8XZvN69PR LSx5xF9ZzXXgW7Y8L//N1yQt79ieEVzq0JalDengOMNn+MrnnpQwyslwdqvei6dzYuPvrgfRyeCi 7hngmJ+OtOJY6lr444AHRvLkkFd74MP/dKsd8VOJd/vxIIfNqarrDY+Z6Yev/Zphp7pXTFFKGslO 2U+TeFftAGno/Kau+PUzG0FjqCRiR3/78KL4kwU1JLQrsShvclObStWMczmV5Od/1Evd8TgFuu0Z zn7SAd+uxCdBGXHPUnApF9EWsw72jY5uEANh7GZjtZDZz2GCS5m9ZgO8/uXOfz8Clo8O140DYqY2 VKscA9nDEipZK4LjkoXYtLc70EhNSZ1zovA4GBnufNANE2tfGm5lwi3/+ed9WLpQO7jWQiLxrnp4 kaH/oLY6G26pGFpCUfcmckUoHi+BP1SgEFPWQDQ+yC2Xg5+ebljBJt4Gg6WTYvhcg7MQpcFmWDyZ F7doERTmDIXw+9YRWcgzM94NjShb2whriEaWvGMYBgNMY4hWRx/iEY/Nu+HmDge3bVyNZmooTM8K eTixIPJ7itwgI9dgo7Rojg1ZLBWP0LQ4drzwZqP6Chk72RqoiKV3arTm0/hXyuqpBlfT0JxJjsUW ErIxj+iMpeWI2A/h1C2QnOHa55h4vMaYJYPB5Jcja/S4Tb3tee95ZgoL2D27tQx+TptZGS3Yz+Dt S0d0IyXi2omqt/BT/1kEcuXeYHjH+c0ScwtynJQ8QjsxLfFeZCOQu/D5nqc1yVD1oZGSLhrTHyXz eCFxFwBHhz2AxuSRsVGVlPIVOpbUZRyR0uY20/iTf4DEnW0wXij79UoooROWHZXlLWl5pOn5KUoG lY8eOSWvZZwUmOeMYkuVmRwa/s5wuUAIv5Q5GqvBhSUS+6CG1JcPPJHoi347q03GiTNbmnOVq2vY BJUpkI2shT4SesxSuLE8DgURJut8XOJy6q+8+Eeg9foXPnZhKKddbqdoC6aXNqIaLWbOIzWZYmSE VctgxUdbH/WStEYE1FMBa5yOK1fm/OMmHm1MPyO5oFBAJBTG4OiBO/9si3CPgyMXFRdAvvpgkOIW E+D6j0R4ascCN5kP7s4wHwKhEoCccsChIIdm/4RuPy83o4dwtqETTO9FzzFd6g4Ekvl1RR1vxin5 ssVOw/Lt7MTap/92o8HXoK19O3UPgaCsdXbqFzHAA1085aO4DZ6PDvsUt9i6VL4jM1a/2mHgcnox K2vMB3SnoYwXVYcoNQ4HVPNQ45WRh5g2/sjbqhESajDnOD8u7SKMXJYIY+amdCByOhxLCSJf5DtX xuL1cPOTLJfHGscIcy1Oc9Eji/nMaE6zIZrCyLWq+c1wjvM+nNgUM8v5znjOM7PStDY9+/nPfs6b agFN6EKfGTnUeJL/oRfN6De7xBxhabSkJ03pSlv60pjOtKY3zelSAODToA61qEdN6lKb+tSoTrWq V83qVrv61bCOtaxnTeta2/rWuM61rnfN6177+tfADrawh21rAhj72MhOtrKXzexmO/vZ0I62tKdN 7Wpb+9rYzra2t83tbnv72+AOt7jHTe5ym/vc6E63utcdbUMZit3wjre8503vetsb3AVh8gLufW6S wggB6fZ3XPhNcGt3pxcFTzizD1CGAxyb4QQ4gJGNbACJU+PYRrb4xKnxoo2XduIAV/bGEW7sK8fC 2AI0cshFHhOMD5wAGw95ygGecgMY2+LicXiyEYLxZVCcACkvuQKO/53yod9c5RE38rGXgfKRJ3ri Ngf6+VaO9KRffNknFzrJNV50jked5QCnl9RjLvSYhH3kX4e5zq1e9aVPHeY/n7i905FsnXvN2Aif iNFhDvCPwNzvCG8R3m2+iqHzXNkDZ/pECN9wlLf87izf+9/3DfQyEODwkK981MfYc2UfHuh4bzne jT4RZJce2ZlfBdEtn/TK71v1BHg55y//8mJEHeLLzvzkdQ772Pud4YrCevB9T3rWM53zuBc8zL+u e87D6Oayp/zLfZ/2eA+L2ZCPOmsHD/q/E97myte+6Kd/7JeDf/iud7zRyR96ySPE4acfeOGRTXnd R9zzrM/66WMf9f9irHz/JSd6xkZ5tBd84kd5Oid/rNd+oyd/kkd/C3h5tjeA5UeAE7F2LhdydJd+ QHd+pBd6MgeBfheANMd65KeBI0h99VYMzeY1YSFzsUB3WRd6adcissB7LQeAFagKQ7d4EFiCQwd8 wid5e5J+pzd/5QeC0CYWXyd4TDeAqReBtCd5BKgoAsiBFWhzuieEyzcssrBsOLdySRZ7FYhsz5ds /6Z8rlda0BcTa2eDCrB2Ybh0wXd3n5dsUwZTKShvLIh94kFyXwh8y1CDewgjieZ4P0WAeDgda/iD rteHkYdsgviI5neF0jd81Yd6+fd1QjiCg1iJijiF9Cd0PoiIi+j/gaa3iZP3hGh4InuXDAXYexF4 hmY4HSmod1dXgKJniDNYDQtYMaJnfxU4cewHb2JnegH4gVLXhoXYjDQnfjG4h1l4eQO4h41XeKWI hld4eKXXeJVHhUqYdOx3hxCYi1yGiVIYhaOnG/8nhYkXgVyYdeejbIU3gZcXcsxQhhkIdsS3egi4 cwMneO/2jcVgd4rCheQ4jdWYifBmj3gXdgJIc69IfrNAiFT3jaKIeM24d0f4eFfochy5gaXHjQv4 hREXfQ9YgPS3ed6Iex1JgAcQkwIocSdpijapkN74d/i4duLheSEHebAYelU4gtm4j8e4fzLpcud3 kU8IlMF3hhvI/33TV4zx5n8VV5GsdRG0x3y3GJX51nGx+Hcz6Hor1356yJKA112SWBa3I4YBqZYw UnELsHbvl2/JthHVMAv0R3pXtyeRpign4oFy+XGI+JPTV4QnOZeRVnz695FkEoAfIUBNSHl6t5iZ CHwnRy9/SR7YyHA9+G8+95gFyIPdVYQFoQoFQZaFyW8vWA02dwA1lgxaGJQlh3rKsHmxqQr3GJTJ gIE1Ro/K4Ju9WXIIIJyxWX2/GXHFeXO36ZPNaZu5mXa6qZy6CZu5mZy7GXLW+Zq3+YK0iZ3ZyYnD iXIYuJvEGZtrFxbn+ZzOuZxAd53K8J69YHfRGZ/ZaZ3uKZsoVyRjs6mf4KlwABqgAjqgBFqgBnqg CJqgCrqgDNqgDvqgEIqgEQAAOw== ------=_NextPart_000_0000_01C772E5.64B18020 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.fda.gov/cder/templates/graphics/fda_mast_03.gif R0lGODlhdABGALMAAP////8AAMzM/8zMzJmZzJmZmWZmmTMzmTMzZgAAZgAAAAAAAAAAAAAAAAAA AAAAACwAAAAAdABGAAAE/zDISau9OOvNu/9gKI5kaZ5oqq5s675wLM90bd94ru98nyXAoHBILBqP yKRyyWw6n9CodEodIqrYrPYJOGy/YPAAUAibz1EDAGBAGNDweJGwHiToxTVA7tzz52sECWoAV0N+ flCJfUeLf0FjAIKEdkSJiJiXiAl6nHtrQaCco55CoqKPQJFvlEaXpJ9AsaOgm7aypbO4tKlACHpv dACVeaGetbudm7y0yriLt6mEXQmRgl7FsKbP3NrRyaTgjnGtCNaDAq6ox+yyn6+zmdrhpfRxwnYH wHfrTeO9cM5Nu7KqiKFGAP8UpITgQMEi2BJKVLXGC75B+yZqNKKPDT9JGP+HHXRlDAm0KP96EQo5 KdCSVybncdlYbVhNO8IEvSyJ6lSufj41pVQyssqYN2uQgmSiBxmzWMtgvntKM6mnAx0ZPevELt4u d16XTfxVKKu+dP6MneQVlae3r38QEDAwd4CAU2Sypk2Gt57XUFNh9ZNzt2nFBB3l2qTJ+FfdAQPa UBxwwMBdnYwnEhgwl+OYdAWSuik8F2vme4YHFIgIRJjSOoYXJyh6WghtJgawbjYs2d0kykEsuzxU EgvXneQi1fGifA1aJFdgOjloSPrpacOwISjMVO3Wen7pjQuqyR1gwEOfCB9+lGnTt9GmQvPZjFvY bmCm3QHevRtUvn8R9x64PMyAhUkYakD2XH9s/UdVF79gQ2BxbxW4zRcC7EYMg7f8Vcsevxx0nDNu gafMYEbZscoBt9W2UXvTbOhiZsMdsNqMM+oRWYs4bjQNZj0GKeSQRBZpZBixJankkkw26eSTUEYp 5ZRUVmnllVJCpuWWXHbp5ZdghinmmGSWaeaZaKap5ppstunmm3DGKeecdNZp55145qnnnnz26eef gAYq6KCEFmrooYgmquiijDbq6KOQRirppHJGAAA7 ------=_NextPart_000_0000_01C772E5.64B18020 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.fda.gov/cder/templates/graphics/blkpixel.gif R0lGODlhAQABAIAAAAAAAP///yH5BAAAAAAALAAAAAABAAEAAAICRAEAOw== ------=_NextPart_000_0000_01C772E5.64B18020 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.fda.gov/cder/templates/graphics/dot_clear.gif R0lGODlhAQABAID/AP///wAAACH5BAEAAAAALAAAAAABAAEAAAICRAEAOw== ------=_NextPart_000_0000_01C772E5.64B18020 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.fda.gov/cder/templates/graphics/Sm_Button_Bottom_Line.gif R0lGODlhAgAgAJEAAIuHiIqGh4eDhP///yH5BAAAAAAALAAAAAACACAAAAIJnI+py+0JRBAFADs= ------=_NextPart_000_0000_01C772E5.64B18020 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.fda.gov/cder/templates/graphics/Sm_Button_Home_Off.gif R0lGODlhVgAgAOYAAPNzc6ysxuysrHNzpvk5OZ2amzk5huDf3/f395WSk56am+nJyQ4ObvwcHOjY 2P4ODlZWlioqfkdHjsnJ1uu7u/oqKvdHR++Pj4GBrvGBgY+PthwcdvZWVru7zu6envRkZJ6evtjY 3tzc3GRknrKwsODg4JCMjYiEhaGenpSRkuPj45mVlpGNjqShopOQkZ6bnNnZ2cjHx/Pz8+/u7uPi 4pqWl+Xk5OHg4e3t7a+trZWSktfV1pSQkZWRkvv7+727vLSys4qGh+Tk5Ovq6qilpu/u76qoqe7t 7tnX2Pn5+ZaTlOHh4b26u6Gen6elpZiUleLh4bWztPj4+J+cnZaSk7y5uvHw8YuHiPHx8eHg4LSy spKOj6CdnoeDhAAAZv8AAP///+bm5gAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAACH5 BAAAAAAALAAAAABWACAAAAf/gGBgOFUmXYeIiYqLjI2Oj5CLLExYgpaCWS5dOlwoXJ+goaKjpKWm p6ifnkpdLkiXYEUJQSQiYbe4ubq7vL2+v8C7IlpdPDOXP10kwczNzs+7QF1Rl1spMNDZ2tu3IldN PpZdBdzl5sBLL09H4uTn7/BhKkYsNu3x+OUqTiY09/kAoZVYQWXIv4AIgx3oMSXJQV0UMlxwcEsA AAAZBFAMs+CixwthLngUsEBXAA24JgzIdyCBAgQPcX348uDBFwFhAHzZ+aUChTACeO4kEIaA0Ac/ cQ0wgCuAF5YuYQoat8vDFwBhHFggCoCoAw8PiAbdRQBrGAoNLORa2vQpvpYv/2MWJXqLQoWOdMNk +OJgrK6yuDjkDcP2ltNbEyBAmBBG5dIBHSQsNiwBQy+4UsFQ1XV1V1dcDm4GFUCaZFGzCxp8WBsh gGsMT0F4MbDBi2svDCTgNsAAQpgRXiQwiMALs9wvIHV9xiVaaGejPBuUVOqluvUwBoiH2SDBaYAw DJhq2BDGy4jGXkDsMj7VXS7knvMuaF7aNIGyFb4kVdr69VMGK4UBgQFOMWbASk514EUEBhjgRYC5 sKeZe7iohssCFViU12h+5QJYGA1UoEthYRz24C0jEOjWgSXa5gUEA8T4nS4SbpYLBw9MNxNeuBDw AFBfkGWWVcndQuJhBkhwS8EE3a2IoBcheGFZBwZ0sF5UcjnQwBccWPCFWgA0AAAH+eEUlEcXndZj AxsRxpRhTw3wIAReaHAYdk9ixwAGDDAQwpVxtccLBRY80EAGFOlEkwUeVORckB8CmYFSb7Z4y3gb oHQni4eFMMBw6gGamY0JlVocloKaqiqNqE646qu31EghrKXKSuuqB6Twwqiz3hrQQDVYIZev+QiR wwk7DEssPjF00YIMqS6LEBREOHuDFJFkq+223G57QrfghituJIEAADs= ------=_NextPart_000_0000_01C772E5.64B18020 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.fda.gov/cder/templates/graphics/Sm_Button_About_Off.gif R0lGODlhWwAgAOYAAPNzc/k5OeysrHNzpqysxjk5huHh4ff395SQkZWSk6Cdne/v756am/oqKlZW lg4ObujY2Ou7u8nJ1kdHjo+PtvwcHGRkntjY3unJye+Pj/4ODhwcdvZWVvGBgYiEheXk5J6evru7 zioqfp+cneTk5I2Jiu6enuLh4fdHR93d3YGBrvRkZJqWl7WztJSRkpmVlp6bnJWRkpGNjvT09Kel pezs7KOgobGvsIuHiPDv8KilptjX17++vqGentfV1uzr65eUle/u7ujo6Pj4+JCMja+trY+LjO7t 7tLR0snHyJiUlcjHx+bl5eHg4aOgoLy6u9fW1rWzs9va2qmmp6ShopyYmbGvr87MzYuIifv7+5aS k5GOj6Gen4yIifPz8+Hg4KqoqYqHh7m3t+Pi4ra0tOLi4qekpLSxsvn5+bu5uYmFhtrZ2evq6pKO j/Hx8fHw8aShoZCNjpmWl/Dw8KCdnoeDhAAAZv8AAP///+bm5gAAAAAAAAAAAAAAAAAAAAAAACH5 BAAAAAAALAAAAABbACAAAAf/gHiCg3g1ZyV1iYqLjI2Oj5CRko1xaXOEmINXJWpydJ+goaKjpKWm p6ihPXRAHm07mYRMYVhPBnm4ubq7vL2+v8DBvCktdQhBsYJmdTzCzs/Q0bxkdS3JMzEJJNLc3d64 KThcWbEfMlPf6erBZTBKR7FrJVHr9fa4JGAyH7FQXTf3AqYjQYPImFhfjDgRyJDbiRda2MRy42JE w4vPDMQYgSbWAgQKfkkYICEXSW4XeEUAkAECrgwAWArIJSCmzQx5bAIQgKGXgQQMDngE+YuCHQu5 7BCQVmCpLg53NGi4EyFPgDtY7zToCSAr1gB5vEatuutn0KEhfU14sCGpU2hK/3WZuNMhD4QGYAOA hdDhDoecYHfdmZkngoYVvMwKzfQxLa8LdlTYCYHraAELKfMQmDAgJQEKuCh8tuOgJK4GKGg2gKA3 V1fAvAbnal0W6GJMjX2BsHNhA9I8duwUeFAgzwDhDx6MLJ6nwACjpXPdAcCLdmGqABoI2C7Apew8 AjTUrX2WMdFeDibksdAWuIM8uyU8eA95wADmzoG/DWuiemBcg3Xl1UxiBdATebcRklsvxA3gwGTA gQYZAXaAlocInOE3gH66fKeLdQIEqB133nGQXQUHIohWLxQW4OIDSMWlnx0g4FJAhjZuKCMuGlCH SwRbWZfBHRgA8J90M0Ggwf+RuSi2Ii8WiJCLA21VqJlSR1U2gArt2aHjfhygiAtUGFjXQAWwCUZY X4Tp4qR5juniWy67hWDHAxSI0JYDDwwwgVIUOuhlHhtMYJpdU62Agl9WVQBAmFTl5OhNYbVZAZoq wsmLnW/VJ5wdhuZxwQDEOfUghhset2EuESzaQAcuXXVHBRz0l1OBleYyJE5u2vYkRsD68iZu5wVr bK/lERvnscYOq2CxzDbrayY5IGBRtMca4AIMCQ4ixBY2YHvsQyy8EUsSdYghrrEfFOGBD5n8wEId SKxr7BJ1wOHFIAdIUUUdVnxgb7An6FAHFU0M4cEkDDfs8MMQJ7JwxBRXbPEDJIEAADs= ------=_NextPart_000_0000_01C772E5.64B18020 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.fda.gov/cder/templates/graphics/Sm_Button_DrugInfo_On.gif R0lGODlhWgAgAOYAAL+/2Q8Pb19fn/39/d/f7B8feW9vqZGNjq+srZuYme/v9U9Plezs7PT09J6b nJ+fxa+vz4+PvC8vgs/P4o+LjIyIid3c3ImFhp2am7KwsO3s7K6rrNXU1PLx8dfW1o2Jio6Ki6Og oIqGh6Gen6enynd3rZ+bnPj4+P7+/qKfoJyZmo+MjcC+v83LzJCNjuTj5Pf399TS05GOj+3t7e/u 7paTk5aSk8rIyPv7+6Cdnvn5+ff29pSRkujo6Ovr64uHiIiEhd/d3sXDw8PD2767vPX09Pr6+rm3 uL68vLCtrrWzs5uXmM7MzLGur6mmp+Df4Ofm5tPR0vb29vz8/NbV1bq4uezr65SQkd7d3eHg4ZyY mZiVlsrJyeno6O7t7eHg4JeTlMnHyLe0tbOxsZKOj8bExcXDxKilpqekpIeDhD8/jH9/sgAAZv// /wAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAACH5 BAAAAAAALAAAAABaACAAAAf/gG2Cg209SRdpiYqLjI2Oj5CRkowfYjOEmIM3Imk5aJ+goaKjpKWm p6iiGGkuVJmEWWlXTAOvtre4ubq7bTBlIBRWtyMXHry6D2trDwDHzrtcaU22HSAjKM+3amzcbAvZ 4JlGZEsnr18UVeGvamttBAZsD+v0TjY+rxwVYfSY7YML1LR5EEENCXdtAMxTYEBNBIT9BB1Z8eRV lApCIg76J+hBgDbbCpRgI2iNwAUBFnDTKEgJBSyvLHzIwBIkRAAk1QhISLKNSQVsILSJx3JACh5Q XtGQgaAmR5853eEsqQangjYQekYcgEGFlFcMDjRl+dTAx6o8qVrFqrXfAAcJ/xqAFesUIYEAO9FO YEMApJq9zda0pfc27tyxGtW0W1AgwFW0bbytCSCwcbzB6wrLzRQWccRtbCQYmCAIcoQABSQIVLBG ggDM4TQfrvlMgZq+p4vC3YypM+1nEkQHMKDbMGe6v48REPB06+7ZuABAxDRhTTONV5kRfn7c8yvB tgIEiKBRmc3txnsjvwU+EwE2pBO7m9A3M3f13jOBBwCBudDXaxDAmgD1KbMACcmoAQEE7VwFjxoG KABAAVVpN2BfBKzBoABX3SJbd7mAJxiFfAE4BGrbCMUGaiORmJI8bRRQgAB4TVhVO3eRCAFO3uCF y4f4hUjSZG0ABcBU7S0gQf9k8whGwHvECSDABLcNJdA/7ZhVWlVskNfQj/cR4hsuIn4T2ZE5CQTV mT59FJlQJr1TEBtXutOOYiWxgRNpcXoY5iBjsjckQnpOpYaZEZDUU596+nQbagIEdN6diOq5qJq2 AEmIBgdsIKRPhKI5lJsCFBAZVYI0alKiV32J5RqlCqLkVI7+iIEWRbzyAgU0kTloqqLiJMBk7lwK rKNZERRaG7O2IyyxtPZpCwopgOHFK2YA0cKn5p1JKwBqFPDAVcayGedrBRAFwXD/gCtuWrXigoQI MWTSRQ1paJDcvs4EkYYJHQyygwdbpMECvwjvMsAYaYRgwQkhJFBBGkRMkfAZxbjokEEaFJhwwQ8b WFALxiS/ggMHZ1QQCAA7 ------=_NextPart_000_0000_01C772E5.64B18020 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.fda.gov/cder/templates/graphics/Sm_Button_Regulatory_Off.gif R0lGODlhXAAgAOYAAGRkno+PtlZWlg4ObtjY3hwcdsnJ1kdHjioqfp6evuPj493d3ZmWl5WSk/j4 +KShopSQkbu7zuzr64GBroiEhZeUleTk5OXl5aypqt3c3PLy8tnY2KimpvDw8J+cnY+MjKekpNra 2pOPkKajpN7d3uLi4szLy7q4uL27u42Ki9jX16ajo66sraWiou3t7fr6+tva2re1tYmFhpuXmJ2a muvq6qCdnZGOj5GOjpKPkI6Ki+Dg4I2JiuHh4XFxpfX19e3s7MfFxpqXl0tLkJCMjbGvr7Oxsa+t rsrJycXDxFBQk7Cur9bV1peTlPLx8fb29vDv8Li2tuHg4eXk5efm5uXk5N/f35mWlpSRkp6bm/39 /Z2ZmuDf35OQkfX09P7+/t/e3paTk93c3Y+LjPf39/z8/Ozs7KKfoK2rrLKvsJyZmpmVlqysxqCd nnNzpjk5hoeDhAAAZv///+bm5gAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAACH5 BAAAAAAALAAAAABcACAAAAf/gHKCgl8dIUc6cIqLjI2Oj5CRkpOPOFEag5mZP0kfFBU2baKjpKWm p6ipqqulHg1wTRmamVpiYxQxJHO7vL2+v8DBwsPEwCFFcAxOs4JPI3AnxdLT1NW/F0twKMxyHRUf O8QBbuQTbNa+bgbBBOjCGxQcZcwlN2cWxG9x+/sC7rtxzv0C4OYfMCtZtkBhpiIFiwv53uwiICBO O3cBgb0paNBXCQxYqDBjwgMDxGFvJO5ik9GAmwMCKb4B8CZCAAC7bs7JmEDATAIBBhQIMIfNAQHr Isw8MIToHJ3CenDoUoUZGCJq8KFUaUDAgDkR4hSoWPDAAK8B3ahUu5ONgThH/wcAYFPgDRs3cAsE ZClUCYJdCHAKW1BhBhBmLsJcUZCPX5wBE+YA+Cp5AIE4RBOkXSsxYIADu3zO2Tjn7K4CMOMkmKPZ wFuBwRaIWPGCmYQGDBijRJAAQBzBbwakRBAwzrrLdzm3LQqAuETSmEPbtbhrQICgxBZAeODANm7d wlLuwnvuTQFy5Fge37zrQGc2mhG8fF4w+hyfLHkd2O9vmHbu3uUW0UQFFHAfZQnUFJ1mdxk4R11t vfHXHAjQV1p/qOWX0wADrObfdt3NcpuAW/ESAGYsvREUTsGhxQZLblT0HgAF9BaHRAfwRtYBKMbB y2XUfQigiN8RA4Bg7flj1P9ZFwWwUUaTBcZiBAbweMAEEiUw1lN1naNUL2+Alh2IAYLX0WjnsBTB mcFYV8x/IWoyopkdHVAAjSqx2UsACFj2JplEksimSxtdpKeJb3g45pByFkkNUAStE4w6vbDh1KGL xpnJnNREMEAcxHUYTEa8sIVppmVOQwACBRxnXjBsGDqHqacOBmijgooTx5orIQDpLgAQVRNrYdI0 hwE0wfSUAD4B0ORPcxCg1qV/Mrqpo8X4Boyp0L14o3OjnVfAV3jdGUdkfU4mAAFCyTgNnKlKI15R 6BG6S7c0AvaGAXYVZRFe7WwUFlFOTmDcU0GiGiidwog2Kz/J3VsfG2/0x5bTAVh+eteEKalX6o0S kqqwJmY0sAbDkybcFrcTVywdu2P5FvFo0xnqxgDoUVpMBjm0oOkgU4hAg1bFvLXuLmHNjHNbOZ5W M2vs0czSapr5cLCTsgpDQgUeYDILEnAYUc2JcQjA4wAGnEhTHBNrxuyNbwWrMbcSFegGAkjdiFee xCiQhgwbzFKDEHCYYE0CZuF9kVfyCbsmG6weOWuBWCYAleQunbVmV5pTEwQcIHgxCBkwMAAHGijX qro0XDwDghQOUEDJ7LTXbvvti8iO++689z57IAA7 ------=_NextPart_000_0000_01C772E5.64B18020 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.fda.gov/cder/templates/graphics/Sm_Button_Calendar_Off.gif R0lGODlhWgAgAOYAAKysxnNzpvNzc/k5OeysrDk5hg4ObsnJ1tjY3ru7zuXk5I+PtpCMjZmWl+zs 7PT09KekpZqWl/4ODhwcdlZWlp6evioqfujY2O+Pj/dHR+nJyWRknvoqKkdHjvGBgYGBrvwcHO6e nvZWVrCtroiEhZmVlo2JivRkZI6Ki+Xl5eTk5Ou7u4yIiZ2amomFhvj4+I+LjN3c3PLx8amnp46L jO7t7dPR0rm3t/b29oqGh+jo6JGNjr+9va+tre/u7t7d3eHg4aakpJSRkre0tZyZmr+9vouHiImG hqKfoLOwsZqXmNfW1qOfoLSys+zr6+Li4pCNjpuYmczLy5aSk9XT1ODf4NTS0+fm5vf29qGenpOQ kODg4Li2tsnHx5iVlqqnqLy7u+3t7evr69fX19XU1Ono6I2Ki/X09MbFxe3s7Lu5usXDxOTj5J6b nJqXl+Hg4KajpKypqpWSk6CdnoeDhP8AAAAAZv///+bm5gAAAAAAAAAAAAAAAAAAAAAAAAAAACH5 BAAAAAAALAAAAABaACAAAAf/gHeCg3c6Iy50iYqLjI2Oj5CRkowmQ2GEmINdR3RRc5+goaKjpKWm p6iiJXQwVJmEQHQ7RSp4tre4ubq7vL2+v7lbNywoTq+CWS5owMArAhgXthgCzwS309TUGhrZHgTR zL1gdCPHMmZEKeG9InUS7xp4A3X0dRm28/V1BAT6dQPreD1h0ODFqzcoRgTchaGOBzwXOIiQJwCP Bg91MMgDiKufrQsC6qxYqAuJEDGvyLBQQzIXiHu2QgAcUNFWBg4bc3m8VSdES1w9YFR5ZcMIl588 a+KieStEHXkc+PHDsxNPyHhI8cSh8eNVDBMzsuLZp4upLY/56lH1d0KsghZa/6688gEliFiyuczi aQhVqrV+1CTAzKqghBIcrxwwgCBWwsOzHDToDZmz41M8Th8jVdAgwoPEi8WKAIE1gwSKHwVXvlV1 gARwPzl7Bs0464V3J+ZVHEAzA4jX8kBkE8Dv8lqlLWV/zqS4dlYCGepw0CiPHggR1qrrI25c3unN nZdjai62vHlcymmfX+82vHr28EmmZx46vv1w88fXX3eAgoEJGyCwywIbLFRAAublRwh5AVkAYAAG BLBLAAUsZAcACbpHn3PMBGAHgngsYICAeCRwgC0U3gLiLQesiAcACFxoS4u4HHAifhrqxyEwBVR4 ywIIHDCBHXZUmGIFQx6IR/8BFhBZIAIG2BElhgUQOSIAUtpxIzAKDsJgOHZImAsFBRzgYQIUQklB AgVMsOQEAHiIBwVwUnDhAh8CECGWFHywTpeCfMlMmLokkAACFVxIIZYLAPDBhwVQUKKWBRSIx4UH VPDiBAFg6SKXOS64HzMWiGkLhgk0OeWiRLYKQAFiXmiHpnjAiUAHrXZqx0KA3pEGA3AE1IEFtySK pAUwKloAlicGuWSsWEK7gQFAwoolryW4ccYrbNAQ1jp82mjBiHYsgMejcZZpxwcIjIsArLZcOCwC eALQQQeT6rpQCi3IUcMra5DAw0IeWmluBwYUYAC1KW6QpYTwXgqAnkMaAABangobQMG1CyWRgxWZ lDEFHWOQhCaQttAbwAGNXjxjALQ2imKzH1SwwIkVdHqxmSRJQUcbMgyCxRJe0NHEfUgzo8IXdDAR wwskTCL11FRXbTUdUV+t9dZcSxIIADs= ------=_NextPart_000_0000_01C772E5.64B18020 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.fda.gov/cder/templates/graphics/Sm_Button_Audiences_Off.gif R0lGODlhWgAgAOYAAKysxjk5hg4ObtjY3o+PtlZWlhwcdioqfsnJ1oGBrru7zkdHjmRknuXk5JCM jZ6evpmWl/T09JqWl6ekpezs7IiEhbCtrpmVlo6Ki4yIiY2JiomFhvLx8eXl5d3c3J2amo+LjKmn p+Tk5I6LjLOwsby7u+Df4O3s7NfW1pqXmKqnqKOfoKajpMzLy6+trcnHx+Li4ri2ttPR0piVlqKf oL+9ve3t7dfX15yZmuHg4JWSk+/u7sbFxeno6Ojo6Lm3t+fm5tXU1KakpImGhuHg4d7d3be0tfb2 9sXDxPf29pOQkL+9vqGentTS04uHiLSys42Ki/Pz8+vr64qGh/j4+PX09Ozr65CNjru5uuDg4JuY me7t7Z6bnJqXl+Tj5NXT1KypqpGNjpaSk5SRknNzpqCdnoeDhAAAZv///+bm5gAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAACH5 BAAAAAAALAAAAABaACAAAAf/gGiCg2g+FhtmiYqLjI2Oj5CRkowaRjaEmIMvQ2ZaZZ+goaKjpKWm p6iiF2YgX5mERGZhSyJptre4ubq7vL2+v7lZPxkYVq+CTBs8wLwICQ8IzLwK0QMJCQAD0rwlZhbH HFA4Hdu4C2foAgrluAFkaecHZwDsuTAOEFSvORgW9WkIzhAYAEBAgX9pqKU5kyBNNoS3aIyR8ipI Biz/yJzRlobMQQIPGBRYZ4vAAnq2EBRgEI0AAAJnCgAgU41AgQf1XIAw8UqGkxj/FJwJQKDdGQMG BCAYcEBAgDMM0sBEaiCNOwZnDsAEgECAAHkot4EZUeSVBw0hECYQcMagtgBV/9MIIANzXYKNBw4A PPPA3UJ68zS+PbitwQclQF7tuCIE4gCTZxZYJbzA3RkyHuddbvdu3t8Aev81uJDiyCsKDib8I9DQ 1t0BftMUcOc0gG2hRW/59TzPNsIGECREOJ363wIDHGHCDmDLwALBDlkatCWgb2fAABgIsFWAsDTg womrrvcgawLtkp9iFih0wd2qBQQQwAr7+l8AUAnILwd+eCbU49VDBluRvSWPAbkB8NQB6wwwoAEN 7YadVAbExE5/4kGkS2wadojhf8V1qNs7Imr4ISYAlmgLA7mpKFpw/qEYIjMKhPULVwS5+B2MGUpT YTTAXIafjsycSEiKNB7V2v8vl+VI5C9GDoIkMAwcUEBoCJA4U0nuXZalLQ6SwREZAHQHpIMMkKSS mLYo0B1OvUQpyJS/GMBAedEM2dEZadwlj5B8PiAAUgIA9tWgaZRnQFOPDeUVAgEFwBZJu8iJBp29 CLUOQw7xuWcaBhwkFJl8gmbLAZJBlSifC+g1gHzOpTGAnWslFACclfIIYoC+3IXZop3aotFCuR1A 6kLukOEbX8GGistQvwYglEGU5hrersz8ic4ZCOg5LLOgHnuUbQFE5dmQm92SFblRAXAOuNbGSMgJ DrAATEBwDsCQngXwuZm+x8baUVHnlspcGgfcFZWDLkWFgMCVXtBFFa94MUKFWr/cZQ6DMenHqnzn HBtfZg0V3NFcdymwgHzysCaQoC3q0sEHOmzxChIV1ABMAJLdkjJWMfE5QL+DHusgW4SZfPRcsg4o wMJPxcQRLyRM0UQmPYhhxg1Pdl1OC2ZwwcEgSaAwgxlPeK02MyKoYMYKHkRRwSR012333XibMXfe fPfttySBAAA7 ------=_NextPart_000_0000_01C772E5.64B18020 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.fda.gov/cder/templates/graphics/Sm_Button_Archives_Off.gif R0lGODlhVwAgAOYAAJ2am/Nzczk5hnNzpuysrEdHjvk5Oaysxo+PttjY3pWSk8nJ1u/v7++Pj+jY 2IGBrg4OblZWlioqfvoqKv4ODmRknhwcdunJyfZWVvwcHLu7zp6evvGBgeu7u/RkZPdHR+3t7bKw sJOPkJKOj6Genu6enuHg4IqGh9HP0N/f37OxsbCwyK+trvDv8I6LjJCMjZqWl/T09Pf399nZ2ePj 4+/u74+LjKGen9rZ2fHx8cnHyLu5uby5uuzr69DP0JaTlJaSk5OQkefn54mFhrCtrtfW1re1tY2J itva2uXk5OXl5ejo6IyIibWzs5SRko6Ki728vNzc3KakpJyYmamnp5iVlpCNjpeUlL27vJWSkuTk 5IiEhZ2amqCdnoeDhAAAZv8AAP///+bm5gAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAACH5 BAAAAAAALAAAAABXACAAAAf/gGGCg2EgTTZeiYqLjI2Oj5CRko1WPCCEhCguQ1VdJF2goaKjpKWm p6ipoJ9ZXkEmmGFCTCc7KWK4ubq7vL2+v8DBvFEhJwo1mFReUMLNzs/QvCFeWIQxVyI00b0dAQ0O uA0B3gS5BOPoDWLoAQQX27wzTiOESSNS8LsYYBT97wZgAoKZAC6AwIAGxBzk1yGfLgBeCOF4osIh Lg5g1DmYgEGMgQBiHGDsGCDhLjDlxHSg4MEiLoiEihwh4pJCR1wlJngEicvgOpO6UOYyANQhzEEm XnSx6CAjr4/mwFwIMIGAVQLghIohQIGDSzFHBeX4AcAiAa26oOJqem5huYUG/965DBuGgYKyDjug HcpzK0qqV7EqxEA1g9y5EQfZxevQKS4CEy6oFYNxalFcQh1QuJyP7mKXHwji+gDGgdqNGX7y0opR HWJCny1e6OcBYEuiATBkANMwQAZ26tBmSP1a8d2vBEhPcA0QTAYMJXrCVZhSTAPHRhMLiv21u3ew 2use/07eoufx5dNHO88Y2oIBC4QhOKDrAAL1u9jDq/DlgTABA+gygAD4PRQed9BYYAGBwQCoywIa FJiLftFo0N8XCeAywAMFLJDAAAVsIIYAFURQAH32HRCgGO9lyCF9LFYggH/bUAjNABaI8cV9On5h wQoQWBDBFwsI8IUEEnyhwf+AFkb4AAQJWABBAV9UIIYEAiTJIzQ2PiOBlQUUgMuOYgyA4YgPCACB GAl8oSKBFvhXQAQIEClGBVB+sUECJ9Z4IHrOLPBFBAOe6aYYEUigiwBi6vjmnQK0uYGZAmT5xZVf CLAll+G1AAQXSkDzZKVG3ndoAQzi4qCjA4qxwY6XDgDBALQG+KEFVfpJyBIi3BBNmLlIIOahZuIy 56putioGBMKK8cCZCHRYQIao6jqIDl4YAU2bWz7bJoqDPnsAso8iSqagAA4qaIgWWLmedj3A4IUP 0NSZIS4W1gnjuLOOuGKyDNYZnxgHUNmhGAhAAEEEA3MahgxITOEFC1pIaPETLxBtMcnGHHfs8ccg hyzyyI8EAgA7 ------=_NextPart_000_0000_01C772E5.64B18020 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.fda.gov/cder/templates/graphics/poweredby.gif R0lGODlhcwAXAPcAAKzF7fPx8bQTArrD1+br9sLL3TJarOLf0rbG5v359rRjWvXhmPr087VMQp8g E9fHiPry1LMhEtvl9ffrt1m0WXWKuJaq1fXdd8GZlNCwqdTd8hNIvAQ4semil0R52SVHjue8t4yr 5KOy1PDq2rWKAOfNafb5++z27M0nEfn6+hJGrDZx2MUbC/bZ0+aKfUNmr9Pc6psEAHCd5/H2+fXl p/X07jZgtYqdxv3++9lLN+rt8urdvOjw+gBDxmmT3Ac5pd3Evq4BAO3DI/3v683b8qc0KViNWtyi m3eh5zhqy91ZRp215Ja27AAvpI2z7OuflPXSzO20q/f59vr8/pQuJmB8tvn15vLFvZu77XOOxs3T 4uT04u71+QAttShdyEqsSeXo7r2VDePl7NyCdLO+1vz+/vz8/Pvp5P/8/fz9/8LU8uLx4EaqRuzz +sEGAHWV012EzvrxyIKl4dmTihBNzP///v///f///EVFRP7+/f7///7//f/+/fjb1v7//luG2vLT ZPCbi6+92/HEGcE3JvHek4Cp7+mXjOJ/b+f15rqaKaRCOPHORHyf31SD3V+G0sGlPfP3/OiShc9v ZPDz+UJ/Qf76+ePKcOBnVmGFz7FrZGGLYvDm4/Pw7liL4Pjl4Yigz4mj2Zqnw9Dg9pyw2NuPhfbw 49/DYPn27fz34t16bYiYhoOTveyto/3+/MSCe/Cuo//+/P79/UqDSTOcM1GHUVBqnsHZwAA1wOfu +Ojv+O7Wx/n3+4Kn7AApn6K/7efHwp3XnSxiyitr2UFwzvv67+Hj5l9/v7/iv+jo6ue0AMHR7FmU Wgc/uR1Or4eviOLx3/Dz9f/+//Hb2Pbh25EjHtXg8uDp+PX8/cbhzMnW8dvx2fr7+6+VOrykUu/O TWKM2u/RVtrNrc/BlBtVwXCX282cAHea3MafmuDMicCfL/fSSMlgUXmTxeXBM7yWFFOJ316J1un3 58dJOMGwdtpUP9e3PE6nS+/o5uKUir/Q7OqbkLzT9gAAAP7+/P///yH5BAAAAAAALAAAAABzABcA AAj/AP8JHEiwoMGDCBMqXMiwocOHEBH6m0ixIkWCFv3dscPxzp2MIEOKpFhHYJ2QJSOqxDhyIsuJ d/610aBtFA8cdey03JnRjhRkwe7d+gcy5cqjREH2czmQJI9GPkKFKOfBExYdOnlq9SftBIVKAZJa NIpUZcil/ljaIZKEFKU7de4Q+OOrwr+PW3f+81pJitiKdfAIxrMKj8J+iAcm/tdPYGPGjh8n9oeY ImK0GO1cEybiX9a0YCpEk3VxoB+Lef7pUd2TI8e9FGqh0bkHY0nDgw87hgy5se/euyVPXIoWc1N/ PmyctGjm3/K0Q65coeZKrMA4E+IU00MR7ow2M3hI/yCQ6EstWSn7XGmRwPk/3O91Awf+2/dl3peJ D2cq0M4oZ6L8BdI/sIwRxT71YAIFUf+kUkIhNITDyAJE3WGCEyHIAI8Hb2ggzxdGCMSAC3N0oIQS LUQkGX70zbcbYxUVx98/fjDxQwECVpSHHq2wE9Y/LaCAwjQN2rMDjWYAokw6/5jgwxJTpOAILp2t wUaIliAyx2pnsFAEAxDdF5liZEb2G1GXDVdZWgPVIUMTA+R40RnzoJPUP5K4ocA/F0AyhUsQDPKO Kfx4YYxnEtBhgBlbXPkPFITg888n+SyCDpgPPVaWnBURpAcSHNwgoB05CRRFBBncSQ0LVIzgjjdp TP9kRxrrkCCOIc1o4Rk3HnzAS6MhdhABEB2MAcJqKm4qUEsE1YFFDzbE0p0JADDxyznWBCKAnRPV wUAO1ewgRDd/unQBCeP00gUonv2ThC3/WBmiC6hOs1q3ykLEE0F25EIHB4L8I61mauizgjNcdOCG Jv/k4U8dCeRAhRVChFGDw2kVQsIBEjjzAwJlAPACGP9A4+ghbrziGUn5PkQZs03VEUIXGxCxMqlc rPABNi2wEAEnDA7hAAb/fGPOA3eW0E17YLASjwxJRCPQGiA+yoIAwBDER8sOvTxSZmVk0cQGTETi XhvkfCD1ETE0MMQ/CUyiADf/WKFOGBMIRIMiBxD/VVIkw2wAg0Db0DJLGv+UEgQL+/TRBwiYcr0Q ZWui5bVa/wzwggpePCKHHJlUQYYZMQHRQAOqqHJECmWkVQM96pxyyQMjEGVHGdYsQ0wXdCDwTzbM bPLMFv9kQIUDRSiwiyySM+S1jJa/VNs/YBRQgBZi2LEsU1J0YlJpaaDSHFF7SADHG0sUcEMzHAw+ kB2p/dMJpmQ1f9Dz+0XfMsYUab8HTLpYgQXY9A8ENKEdOZoevuyXEPy9TH/54l9RnKCCZFjHBnZp Sf0YiJE0WaZT+xtJHZDQBVI4R3uRMMAyOMUyDt5PKSCM4EjuoAMbNAEcAFDDL+AgiM+IZIMulJPl Ima0KQkWJQUiOMYxskAKHbAQMEGM4kKMCJKY8EsrQCRIQAAAOw== ------=_NextPart_000_0000_01C772E5.64B18020 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.fda.gov/cder/templates/graphics/totop_arrow.gif R0lGODlhDAATANUiAOns70teeJKerpyntvv8/B01VR43V/n5+k1geYCNoff4+SA4WEZadTJIZjVL aOHk6D9Ubz9UcKu0wNjc4rS8x9/j5/z9/Y+aqhszVFhqgkRZcy5EYkdbdefp7DZMaExfefj5+hgx Uv///wAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAACH5BAEAACIALAAAAAAMABMAAAZyQJFQ VIlEKsOkJREKJSxJoQDTxAiik02zuZkMD5ntNnMQDgriZmEgoizS2wWFARczIA2Pw9A0ODwNEAAd AA8cTRwPgwBJCE0IUUIgH00fIJGTlZdRmSGWmJSem0mdn5wBTQGjQwoaTRoKkQQSFxcSBENBADs= ------=_NextPart_000_0000_01C772E5.64B18020 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.fda.gov/cder/templates/graphics/back_arrow.gif R0lGODlhDAAOAOYAABcwUQwmSQ8pTOvu8YeVphkyUg0nShAqTA8pSxMsTg4oS4yZqPj5+lFje73E zh84WVtuhQsmSNPX3VhqgXKClxUuUCU8XA4pS1NnfhAqTRIsThYwUBYvUGV2i/3+/hMtTxYvUVFk fTBHZC9GYwYhRRgyUvb3+LO8xxIrTUVZc/39/VNmfxUuT+nr7hQuT9re40dactbb4a63w9ba4BQt T5qlsyA4WSI7Wg4oSlhqgt3g5Q0nS8bN1SY+XBErTZGdrVFjfkhbcwwnSf7+/k1he6Gsuj5SbsvQ 10RZc2x7kdLW3O/x8yhAXv39/uPl6h43V7O7x0BVcLW8xi5EYlRmfzBGZBgxUv///wAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAACH5 BAAAAAAALAAAAAAMAA4AAAeGgClMVYSFFkgxVyIAVo2NFQIEV1cdBwWOVjgYA5MnHC6OLAlFk1ct UUKOAD5AM6U/CjRWIBobJFScVxJTBgAlNx8JCAQeV00UARFEDiEKASM6kzxPFzJXUDYCKDWTDCs5 JldLEAYBSZNDL06lCwgHE6XxV1IFGUHypUc9OzAq+FdKjDxoEAgAOw== ------=_NextPart_000_0000_01C772E5.64B18020 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.fda.gov/cder/graphics/pdf.gif R0lGODlhEAAQALMAAMzMzMyZmcxmZswzM8wAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAACH5BAEAAAAALAAAAAAQABAAAAQ/EEg5SJg4A0u0555GEEKYBeRmdmgHXBpMpmro0uLrbqMg WBhSyzcCvVpASSDwg/GcoVYOg/K9VFDJzBTccQERADs= ------=_NextPart_000_0000_01C772E5.64B18020 Content-Type: application/x-javascript Content-Transfer-Encoding: quoted-printable Content-Location: http://www.fda.gov/fsrscripts/triggerParams.js // Customer: U.S. Food and Drug Administration // Version : DHTML Trigger 3.0.1 function cppUrlPatch(s) { var translated =3D ""; var i;=20 var found =3D 0; for(i =3D 0; (found =3D s.indexOf(':', found)) !=3D -1; ) { translated +=3D s.substring(i, found) + "|"; i =3D found + 1; found++; } translated +=3D s.substring(i, s.length); return translated; } var triggerParms =3D new Array();=20 var excludeList =3D new Array(); triggerParms["dt"] =3D 0; // disable trigger if 1 triggerParms["mid"] =3D "oFU8oht9h8gMEgBp08oc5g=3D=3D"; // model = instance id triggerParms["cid"] =3D "5NElN0sYkQcFAAcgcYFYVA=3D=3D"; // customer id triggerParms["lf"] =3D 4; // loyalty factor triggerParms["sp"] =3D 0; // sample percentage triggerParms["npc"] =3D 1; // no persistent cookies if 1 triggerParms["rw"] =3D 129600; // resample wait (value in minutes) triggerParms["pu"] =3D 0; // pop-under control triggerParms["olpu"] =3D 1; // On Load pop-under control triggerParms["lfcookie"] =3D "ForeseeLoyalty_MID_oFU8oht9h8"; triggerParms["ascookie"] =3D "ForeseeSurveyShown_oFU8oht9h8"; triggerParms["width"] =3D 420; // survey width triggerParms["height"] =3D 500; // survey height triggerParms["domain"] =3D ".fda.gov"; // domain name triggerParms["omb"] =3D "1505-0186"; // OMB number //triggerParms["cmetrics"] =3D "90010257"; // coremetrics client id triggerParms["cpp_1"] =3D "userURL:" + cppUrlPatch = (window.location.href); triggerParms["capturePageView"] =3D 1; //excludeList[0] =3D "/exclude/"; //trigger script will not work under = this path //triggerParms["dcUniqueId"] =3D "TEST04JloZZN0k9cI1Ep5d"; // (22 chars = unique Id for double cookie I/II) //triggerParms["midexp"] =3D 129600; // model instance expiry value triggerParms["rso"]=3D 0; //user has chosen to use Retry Survey Option triggerParms["aro"]=3D 0; //user has chosen to use Auto Retry Option, = with SP=3D100 //triggerParms["rct"]=3D 1; //The maximum number of times allowed to = serve a survey to a user //triggerParms["rds"]=3D 1; //The minimum number of days to wait to = serve a survey repeatedly //triggerParms["mrd"]=3D 1; //The total number of days that a user can = be re-served a survey triggerParms["compliant508"] =3D 1; //508 compliant if 1 //DHTML Parameter triggerParms["dhtml"]=3D 1;// disable dhtml trigger if dhtml=3D0 triggerParms["dhtmlWidth"] =3D 400; // welcome page width triggerParms["dhtmlHeight"] =3D 290; // welcome page height triggerParms["dhtmlURL"]=3D "/fsrscripts/FSRInvite.html"; ------=_NextPart_000_0000_01C772E5.64B18020 Content-Type: application/x-javascript Content-Transfer-Encoding: quoted-printable Content-Location: http://www.fda.gov/fsrscripts/stdLauncher.js // Customer:U.S. Food and Drug Administration // Version : DHTML Trigger 3.0.1 // ************ don't modify below this line ************* var popUpURL =3D "//www.foreseeresults.com/survey/display"; // base URL = to the survey=20 var FSRImgURL =3D "//www.foreseeresults.com/survey/FSRImg"; var OTCImgURL =3D "//controller.foreseeresults.com/fsrSurvey/OTCImg"; var ckAlreadyShown =3D triggerParms["ascookie"]; // name of the = persistent/session cookie var ckLoyaltyCount =3D triggerParms["lfcookie"]; // name of the loyalty = count cookie var fullURL=3Dnull; var oldURL=3Dnull; var myPopUp=3Dnull; var fsr_aol=3Dnull; var dcQString=3D""; var cpp_3 =3D ""; var winOptions =3D "width=3D 1,height=3D 1,top=3D 4000,left=3D = 4000,resizable=3Dyes,scrollbars=3Dyes"; var persistentExpires =3D new Date(); //persistent cookie expiration=20 persistentExpires.setTime(persistentExpires.getTime() + = (triggerParms["rw"]*60*1000)); function ForeCStdGetCookie (name) { var arg =3D name + "=3D"; var alen =3D arg.length; var clen =3D document.cookie.length; var i =3D 0; while (i < clen) { var j =3D i + alen; if (document.cookie.substring(i, j) =3D=3D arg) { return ForeCStdGetCookieVal (j); } i =3D document.cookie.indexOf(" ", i) + 1; if (i =3D=3D 0) { break; } } return null; } function fsr_showWindow() { =20 if(myPopUp !=3D null && !myPopUp.closed && fsr_aol=3D=3Dfalse) = {return;} =20 var cpp3Str =3D "";=20 cpp_3 =3D "Browser:"+ cppUrlPatch (navigator.userAgent)=20 cpp_3+=3D";dhtml";=09 var pos1 =3D fullURL.indexOf("&cpp_3=3D"); var pos2 =3D fullURL.indexOf("&",pos1+1); if (pos2=3D=3D-1){ fullURL =3D fullURL.substring(0,pos1); }else{ cpp3Str =3D fullURL.substring(pos2,fullURL.length); fullURL =3D fullURL.substring(0,pos1); } =20 fullURL+=3D"&cpp_3=3D"+cpp_3 + cpp3Str; =20 if(document.all && document.all.fsr_window.filters) { eval("document.all.fsr_window").filters.revealTrans.transition =3D 23 = ; eval("document.all.fsr_window").filters.revealTrans.Apply(); eval("document.all.fsr_window").style.visibility =3D 'visible'; eval("document.all.fsr_window").filters.revealTrans.Play(); } else if(document.all) {document.all.fsr_window.style.visibility =3D = 'visible';}=09 else if(document.getElementById) = {document.getElementById("fsr_window").style.visibility =3D 'visible';}=09 } function fsr_hideWindow() { if(document.all && document.all.fsr_window.filters) { eval("document.all.fsr_window").filters.revealTrans.transition =3D 23; eval("document.all.fsr_window").filters.revealTrans.Apply(); eval("document.all.fsr_window").style.visibility =3D 'hidden'; eval("document.all.fsr_window").filters.revealTrans.Play(); } else if(document.all) {document.all.fsr_window.style.visibility =3D = 'hidden';}=09 else if(document.getElementById) = {document.getElementById("fsr_window").style.visibility =3D 'hidden';} } function ForeCStdSetCookie (name, value) { var argv =3D ForeCStdSetCookie.arguments; var argc =3D ForeCStdSetCookie.arguments.length; var expires =3D (argc > 2) ? argv[2] : null; var path =3D (argc > 3) ? argv[3] : null; var domain =3D (argc > 4) ? argv[4] : null; var secure =3D (argc > 5) ? argv[5] : false; document.cookie =3D name + "=3D" + escape (value) + ((expires =3D=3D null) ? "" : ("; expires=3D" + expires.toGMTString())) = + ((path =3D=3D null) ? "" : ("; path=3D" + path)) + ((domain =3D=3D null) ? "" : ("; domain=3D" + domain)) + ((secure =3D=3D true) ? "; secure" : ""); } function ForeCStdGetCookieVal(offset) { var endstr =3D document.cookie.indexOf (";", offset); if (endstr =3D=3D -1) { endstr =3D document.cookie.length; } return unescape(document.cookie.substring(offset, endstr)); } function specialEscape(str) { var translated =3D ""; var i;=20 var found =3D 0; for(i =3D 0; (found =3D str.indexOf('+', found)) !=3D -1; ) { translated +=3D str.substring(i, found) + "%2B"; i =3D found + 1; found++; } translated +=3D str.substring(i, str.length); return translated; } function Pop(){ myPopUp =3D window.open(fullURL, 'survey',winOptions); if ( myPopUp!=3Dnull && !myPopUp.closed) { if (triggerParms["pu"] =3D=3D 1){ self.focus(); } else { myPopUp.focus(); =09 } } } function checkMAC(){ if(navigator.platform.indexOf("Win32") >=3D 0){ return false; } else { return true; }=09 } var detect =3D navigator.userAgent.toLowerCase(); function checkAOL(){ if (detect.indexOf("aol") >=3D0){ return true; } return false; } function currentLocationExcluded() {=09 var parentURLPath =3D window.location.pathname;//location path for(key in excludeList) { if(parentURLPath.indexOf(excludeList[key]) !=3D -1) { return true; } } return false; } var newDt; var currTime; // in millisecs var OTCImg; var FSRImg; var surveyProcessCont =3D 1; function stdImgProc() { if(triggerParms["compliant508"] =3D=3D 1) { fsr_showWindow();} else { setTimeout ( "fsr_showWindow();", 1000, "JavaScript" ); } } function fsrShowSurvey(){ if(dcQString =3D=3D "") { stdImgProc(); } else { newDt =3D new Date(); currTime=3D newDt.getTime(); // in millisecs FSRImg =3D new Image(); FSRImg.src =3D null; FSRImg.onerror =3D imgErrorProc; FSRImg.onload =3D imgOnloadProc; FSRImg.src =3D FSRImgURL + "?" + dcQString + "&uid=3D"+ currTime; = //for NE/FF Cache Fix } } function imgOnloadProc() { if(surveyProcessCont =3D=3D 1 && FSRImg.width =3D=3D 3) { stdImgProc(); = } return true; } function imgErrorProc() { surveyProcessCont =3D 0; return true; } function otcOnloadProc() { =20 if(surveyProcessCont =3D=3D 1 && OTCImg.width =3D=3D 3) { = fsrShowSurvey(); } else { surveyProcessCont =3D 0; } return true; } function otcErrorProc() { fsrShowSurvey(); return true; } function Poll() {=20 if(triggerParms["dt"] =3D=3D 1) { return; } if(currentLocationExcluded()) { return; } var stickyCounter =3D ForeCStdGetCookie(ckLoyaltyCount); // check = counter cookie var alreadyShown =3D ForeCStdGetCookie(ckAlreadyShown); // check if we = already have shown survey var pageCount; var randNum =3D Math.random(); randNum *=3D 100; if (stickyCounter =3D=3D null) { pageCount =3D 1;=20 ForeCStdSetCookie(ckLoyaltyCount, pageCount, = null,'/',triggerParms["domain"]); stickyCounter =3D ForeCStdGetCookie(ckLoyaltyCount); } if (stickyCounter !=3D null) { pageCount =3D stickyCounter; if(pageCount >=3D triggerParms["lf"]) { if(alreadyShown =3D=3D null) { if (triggerParms["rso"] =3D=3D 1 && triggerParms["aro"] =3D=3D 1) { triggerParms["sp"] =3D 100.0; // Update Ssample percentage } if(randNum <=3D triggerParms["sp"]) { fsr_aol=3D checkAOL(); var fsr_mac=3D checkMAC(); =09 var fsr_browser=3D"fsr_nn6"; if(document.all || document.getElementById){=20 fsr_browser =3D "fsr_ie"; } if(document.layers) { fsr_browser =3D "fsr_nn"; } fullURL =3D popUpURL + "?" + "width=3D" + triggerParms["width"] + "&height=3D" + triggerParms["height"] + "&cid=3D" + specialEscape(escape(triggerParms["cid"])) + "&mid=3D" = + specialEscape(escape(triggerParms["mid"])); if ((triggerParms["omb"] ) !=3D null) { fullURL +=3D "&omb=3D" + escape(triggerParms["omb"]); } if ((triggerParms["cmetrics"] ) !=3D null) { fullURL +=3D "&cmetrics=3D" + escape(triggerParms["cmetrics"]); } if (triggerParms["olpu"] =3D=3D 1) { fullURL +=3D "&olpu=3D1"; } if ((triggerParms["dcUniqueId"]) !=3D null) { fullURL +=3D "&dcUniqueId=3D" + = escape(triggerParms["dcUniqueId"]); } if (triggerParms["rso"] =3D=3D 1) { fullURL +=3D "&rso=3D1&rct=3D" + triggerParms["rct"] + "&rds=3D" + = triggerParms["rds"] + "&mrd=3D" + triggerParms["mrd"] + "&rws=3D" + = triggerParms["rw"]; } if (triggerParms["capturePageView"] =3D=3D 1) { triggerParms["cpp_2"] =3D "PageView:"+ pageCount; // customer = parameter 2 - Page View } if ((triggerParms["midexp"] ) !=3D null) { fullURL +=3D "&ndc=3D1&fsexp=3D5256000&midexp=3D" + = triggerParms["midexp"]; } triggerParms["cpp_3"] =3D "Browser:"+ cppUrlPatch = (navigator.userAgent) + ";normal"; =09 var customerParams =3D ""; =09 for(paramKey in triggerParms) { if(paramKey.substring(0,3) =3D=3D "cpp"){ fullURL +=3D "&" + paramKey + "=3D" + = escape(triggerParms[paramKey]); } }=09 oldURL=3DfullURL; if (triggerParms["rso"] !=3D 1) { if(triggerParms["npc"] =3D=3D 1) { ForeCStdSetCookie(ckAlreadyShown, = 'true',null,'/',triggerParms["domain"]); } else { ForeCStdSetCookie(ckAlreadyShown, 'true', = persistentExpires,'/',triggerParms["domain"]); } } // for AOL users - show DHTML (by default) if (fsr_aol=3D=3Dfalse) { myPopUp =3D window.open(fullURL, 'survey',winOptions); } if (fsr_mac=3D=3Dfalse && (fsr_browser !=3D "fsr_nn") && = (triggerParms["dhtml"] =3D=3D 1)) { fullURL=3DoldURL; fsr_left =3D (screen.width - triggerParms["dhtmlWidth"])/2; fsr_top =3D Math.min((screen.height - = triggerParms["dhtmlHeight"])/2,150); =09 document.write("
" + "
"); =09 //DC I/II verification if (triggerParms["rso"] =3D=3D 1) { dcQString =3D "rso=3D1&rct=3D" + triggerParms["rct"] + "&rds=3D" = + triggerParms["rds"] + "&mrd=3D" + triggerParms["mrd"] + "&rws=3D" + = triggerParms["rw"]; if(triggerParms["dcUniqueId"]!=3Dnull) { dcQString +=3D = "&dcUniqueId=3D" + specialEscape(escape(triggerParms["dcUniqueId"])); } } if ((triggerParms["midexp"] ) !=3D null) { dcQString =3D "ndc=3D1&midexp=3D" + triggerParms["midexp"] + = "&mid=3D" + specialEscape(escape(triggerParms["mid"])); if(triggerParms["dcUniqueId"]!=3Dnull) { dcQString +=3D = "&dcUniqueId=3D" + specialEscape(escape(triggerParms["dcUniqueId"])); } } =09 =09 //Failover Check surveyProcessCont =3D 1; =09 newDt =3D new Date(); currTime=3D newDt.getTime(); // in millisecs OTCImg =3D new Image(); OTCImg.src =3D null; OTCImg.onerror =3D otcErrorProc; OTCImg.onload =3D otcOnloadProc; OTCImg.src =3D OTCImgURL + "?protocol=3D" + = window.location.protocol + "&uid=3D"+ currTime; //for NE/FF Cache Fix } =09 if(myPopUp !=3D null && !myPopUp.closed) { if (triggerParms["pu"] =3D=3D 1){ self.focus(); } else { myPopUp.focus(); } } } } } =09 pageCount++; ForeCStdSetCookie(ckLoyaltyCount, pageCount, = null,'/',triggerParms["domain"]); =09 } } ------=_NextPart_000_0000_01C772E5.64B18020 Content-Type: application/x-javascript Content-Transfer-Encoding: quoted-printable Content-Location: http://www.fda.gov/cder/templates/mm_menu.js /** * mm_menu 20MAR2002 Version 6.0 * Andy Finnell, March 2002 * Copyright (c) 2000-2002 Macromedia, Inc. * * based on menu.js * by gary smith, July 1997 * Copyright (c) 1997-1999 Netscape Communications Corp. * * Netscape grants you a royalty free license to use or modify this * software provided that this copyright notice appears on all copies. * This software is provided "AS IS," without a warranty of any kind. */ function Menu(label, mw, mh, fnt, fs, fclr, fhclr, bg, bgh, halgn, = valgn, pad, space, to, sx, sy, srel, opq, vert, idt, aw, ah)=20 { this.version =3D "020320 [Menu; mm_menu.js]"; this.type =3D "Menu"; this.menuWidth =3D mw; this.menuItemHeight =3D mh; this.fontSize =3D fs; this.fontWeight =3D "plain"; this.fontFamily =3D fnt; this.fontColor =3D fclr; this.fontColorHilite =3D fhclr; this.bgColor =3D "#555555"; this.menuBorder =3D 1; this.menuBgOpaque=3Dopq; this.menuItemBorder =3D 1; this.menuItemIndent =3D idt; this.menuItemBgColor =3D bg; this.menuItemVAlign =3D valgn; this.menuItemHAlign =3D halgn; this.menuItemPadding =3D pad; this.menuItemSpacing =3D space; this.menuLiteBgColor =3D "#ffffff"; this.menuBorderBgColor =3D "#777777"; this.menuHiliteBgColor =3D bgh; this.menuContainerBgColor =3D "#cccccc"; this.childMenuIcon =3D "arrows.gif"; this.submenuXOffset =3D sx; this.submenuYOffset =3D sy; this.submenuRelativeToItem =3D srel; this.vertical =3D vert; this.items =3D new Array(); this.actions =3D new Array(); this.childMenus =3D new Array(); this.hideOnMouseOut =3D true; this.hideTimeout =3D 50; this.addMenuItem =3D addMenuItem; this.writeMenus =3D writeMenus; this.MM_showMenu =3D MM_showMenu; this.onMenuItemOver =3D onMenuItemOver; this.onMenuItemAction =3D onMenuItemAction; this.hideMenu =3D hideMenu; this.hideChildMenu =3D hideChildMenu; if (!window.menus) window.menus =3D new Array(); this.label =3D " " + label; window.menus[this.label] =3D this; window.menus[window.menus.length] =3D this; if (!window.activeMenus) window.activeMenus =3D new Array(); } function addMenuItem(label, action) { this.items[this.items.length] =3D label; this.actions[this.actions.length] =3D action; } function FIND(item) { if( window.mmIsOpera ) return(document.getElementById(item)); if (document.all) return(document.all[item]); if (document.getElementById) return(document.getElementById(item)); return(false); } function writeMenus(container) { if (window.triedToWriteMenus) return; var agt =3D navigator.userAgent.toLowerCase(); window.mmIsOpera =3D agt.indexOf("opera") !=3D -1; if (!container && document.layers) { window.delayWriteMenus =3D this.writeMenus; var timer =3D setTimeout('delayWriteMenus()', 500); container =3D new Layer(100); clearTimeout(timer); } else if (document.all || document.hasChildNodes || window.mmIsOpera) = { document.writeln(''); container =3D FIND("menuContainer"); } window.mmHideMenuTimer =3D null; if (!container) return;=09 window.triedToWriteMenus =3D true;=20 container.isContainer =3D true; container.menus =3D new Array(); for (var i=3D0; i\n'+ '
\n'+ '
\n'+ ''; } var x=3Di; for (var i=3D0; i'; var dClose =3D '
' if (menu.bgImageUp) dTag =3D '
'; var left =3D 0, top =3D 0, right =3D 0, bottom =3D 0; left =3D 1 + menu.menuItemPadding + menu.menuItemIndent; right =3D left + menu.menuWidth - 2*menu.menuItemPadding - = menu.menuItemIndent; if( menu.menuItemVAlign =3D=3D 'top' ) top =3D menu.menuItemPadding; if( menu.menuItemVAlign =3D=3D 'bottom' ) top =3D = menu.menuItemHeight-menu.fontSize-1-menu.menuItemPadding; if( menu.menuItemVAlign =3D=3D 'middle' ) top =3D = ((menu.menuItemHeight/2)-(menu.fontSize/2)-1); bottom =3D menu.menuItemHeight - 2*menu.menuItemPadding; var textProps =3D 'position:absolute;left:' + left + 'px;top:' + top = + 'px;'; if (lrs) { textProps +=3DitemProps + 'right:' + right + ';bottom:' + bottom + = ';'; dTag =3D ""; dClose =3D ""; } =09 if(document.all && !window.mmIsOpera) { item =3D '
' + item + = '
'; } else if (lrs) { item =3D '
' + = item + '
'; } else { var hitem =3D null; if( menu.menuItemHAlign !=3D 'left' ) { if(window.mmIsOpera) { var operaWidth =3D menu.menuItemHAlign =3D=3D 'center' ? = -(menu.menuWidth-2*menu.menuItemPadding) : = (menu.menuWidth-6*menu.menuItemPadding); hitem =3D '
' + item + = '
'; item =3D '
' + item + = '
'; } else { hitem =3D '
' + item + = '
'; item =3D '
' + item + = '
'; } } else hitem =3D null; } if(document.all && !window.mmIsOpera) item =3D '
' + item + '
'; var dText =3D '
'+ item +' 
\n' + '
'=20 + (hitem||item) +' 
'; if (childMenu) content +=3D ( dTag + dText + '
\n' + dClose); else content +=3D ( dTag + dText + dClose); if (lrs) { l.document.open("text/html"); l.document.writeln(content); l.document.close();=09 content =3D ''; theStat +=3D "-"; tsc++; if (tsc > 50) { tsc =3D 0; theStat =3D ""; } status =3D theStat; } countItems++; =20 } if (lrs) { var focusItem =3D new Layer(100, body); focusItem.visiblity=3D"hidden"; focusItem.document.open("text/html"); focusItem.document.writeln(" "); focusItem.document.close();=09 } else { content +=3D '
 
\n'; content +=3D '
\n
\n\n'; } i=3Dx; } if (document.layers) { =09 container.clip.width =3D window.innerWidth; container.clip.height =3D window.innerHeight; container.onmouseout =3D mouseoutMenu; container.menuContainerBgColor =3D this.menuContainerBgColor; for (var i=3D0; i0) { if( l.Menu.vertical ) l.top =3D body.document.layers[n-1].top + = body.document.layers[n-1].clip.height + proto.menuItemBorder + = proto.menuItemSpacing; else l.left =3D body.document.layers[n-1].left + = body.document.layers[n-1].clip.width + proto.menuItemBorder + = proto.menuItemSpacing; } l.hilite =3D l.document.layers[1]; if (proto.bgImageUp) l.background.src =3D proto.bgImageUp; l.document.layers[1].isHilite =3D true; if (l.document.layers.length > 2) { l.childMenu =3D container.menus[i].items[n].menuLayer; l.document.layers[2].left =3D l.clip.width -13; l.document.layers[2].top =3D (l.clip.height / 2) -4; l.document.layers[2].clip.left +=3D 3; l.Menu.childMenus[l.Menu.childMenus.length] =3D l.childMenu; } } if( proto.menuBgOpaque ) body.document.bgColor =3D proto.bgColor; if( proto.vertical ) { body.clip.width =3D l.clip.width +proto.menuBorder; body.clip.height =3D l.top + l.clip.height +proto.menuBorder; } else { body.clip.height =3D l.clip.height +proto.menuBorder; body.clip.width =3D l.left + l.clip.width +proto.menuBorder; if( body.clip.width > window.innerWidth ) body.clip.width =3D = window.innerWidth; } var focusItem =3D body.document.layers[n]; focusItem.clip.width =3D body.clip.width; focusItem.Menu =3D l.Menu; focusItem.top =3D -30; focusItem.captureEvents(Event.MOUSEDOWN); focusItem.onmousedown =3D onMenuItemDown; if( proto.menuBgOpaque ) menu.document.bgColor =3D = proto.menuBorderBgColor; var lite =3D menu.document.layers[0]; if( proto.menuBgOpaque ) lite.document.bgColor =3D = proto.menuLiteBgColor; lite.clip.width =3D body.clip.width +1; lite.clip.height =3D body.clip.height +1; menu.clip.width =3D body.clip.width + (proto.menuBorder * 3) ; menu.clip.height =3D body.clip.height + (proto.menuBorder * 3); } } else { if ((!document.all) && (container.hasChildNodes) && !window.mmIsOpera) = { container.innerHTML=3Dcontent; } else { container.document.open("text/html"); container.document.writeln(content); container.document.close();=09 } if (!FIND("menuLayer0")) return; var menuCount =3D 0; for (var x=3D0; x 0) MM_showMenu(null, = "relative", "relative", l.layers[i]); } if (l.parentLayer) { if (x !=3D "relative") l.parentLayer.left =3D x || window.pageX || 0; if (l.parentLayer.left + l.clip.width > window.innerWidth) = l.parentLayer.left -=3D (l.parentLayer.left + l.clip.width - = window.innerWidth); if (y !=3D "relative") l.parentLayer.top =3D y || window.pageY || 0; if (l.parentLayer.isContainer) { l.Menu.xOffset =3D window.pageXOffset; l.Menu.yOffset =3D window.pageYOffset; l.parentLayer.clip.width =3D window.ActiveMenu.clip.width +2; l.parentLayer.clip.height =3D window.ActiveMenu.clip.height +2; if (l.parentLayer.menuContainerBgColor && l.Menu.menuBgOpaque ) = l.parentLayer.document.bgColor =3D l.parentLayer.menuContainerBgColor; } } l.visibility =3D "inherit"; if (l.Menu) l.Menu.container.visibility =3D "inherit"; } else if (FIND("menuItem0")) { var l =3D menu.menuLayer || menu;=09 hideActiveMenus(); if (typeof(l) =3D=3D "string") l =3D FIND(l); window.ActiveMenu =3D l; var s =3D l.style; s.visibility =3D "inherit"; if (x !=3D "relative") { s.pixelLeft =3D x || (window.pageX + document.body.scrollLeft) || 0; s.left =3D s.pixelLeft + 'px'; } if (y !=3D "relative") { s.pixelTop =3D y || (window.pageY + document.body.scrollTop) || 0; s.top =3D s.pixelTop + 'px'; } l.Menu.xOffset =3D document.body.scrollLeft; l.Menu.yOffset =3D document.body.scrollTop; } if (menu) window.activeMenus[window.activeMenus.length] =3D l; MM_clearTimeout(); } function onMenuItemDown(e, l) { var a =3D window.ActiveMenuItem; if (document.layers && a) { a.eX =3D e.pageX; a.eY =3D e.pageY; a.clicked =3D true; } } function mouseupMenu(e) { hideMenu(true, e); hideActiveMenus(); return true; } function getExplorerVersion() { var ieVers =3D parseFloat(navigator.appVersion); if( navigator.appName !=3D 'Microsoft Internet Explorer' ) return = ieVers; var tempVers =3D navigator.appVersion; var i =3D tempVers.indexOf( 'MSIE ' ); if( i >=3D 0 ) { tempVers =3D tempVers.substring( i+5 ); ieVers =3D parseFloat( tempVers );=20 } return ieVers; } function mouseoutMenu() { if ((navigator.appName =3D=3D "Microsoft Internet Explorer") && = (getExplorerVersion() < 4.5)) return true; hideMenu(false, false); return true; } function hideMenu(mouseup, e) { var a =3D window.ActiveMenuItem; if (a && document.layers) { a.document.bgColor =3D a.saveColor; a.focusItem.top =3D -30; if (a.hilite) a.hilite.visibility =3D "hidden"; if (mouseup && a.mmaction && a.clicked && window.ActiveMenu) { if (a.eX <=3D e.pageX+15 && a.eX >=3D e.pageX-15 && a.eY <=3D = e.pageY+10 && a.eY >=3D e.pageY-10) { setTimeout('window.ActiveMenu.Menu.onMenuItemAction();', 500); } } a.clicked =3D false; if (a.Menu.bgImageOver) a.background.src =3D a.Menu.bgImageUp; } else if (window.ActiveMenu && FIND("menuItem0")) { if (a) { a.style.backgroundColor =3D a.saveColor; if (a.hilite) a.hilite.style.visibility =3D "hidden"; if (a.hiliteShim) a.hiliteShim.style.visibility =3D "inherit"; if (a.Menu.bgImageUp) a.style.background =3D "url(" + = a.Menu.bgImageUp +")"; } } if (!mouseup && window.ActiveMenu) { if (window.ActiveMenu.Menu) { if (window.ActiveMenu.Menu.hideOnMouseOut) MM_startTimeout(); return(true); } } return(true); } function hideChildMenu(hcmLayer) { MM_clearTimeout(); var l =3D hcmLayer; for (var i=3D0; i < l.Menu.childMenus.length; i++) { var theLayer =3D l.Menu.childMenus[i]; if (document.layers) theLayer.visibility =3D "hidden"; else { theLayer =3D FIND(theLayer); theLayer.style.visibility =3D "hidden"; if( theLayer.Menu.menuItemHAlign !=3D 'left' ) { for(var j =3D 0; j < theLayer.Menu.menuItemLayers.length; j++) { var itemLayer =3D theLayer.Menu.menuItemLayers[j]; if(itemLayer.textShim) itemLayer.textShim.style.visibility =3D = "inherit"; } } } theLayer.Menu.hideChildMenu(theLayer); } if (l.childMenu) { var childMenu =3D l.childMenu; if (document.layers) { l.Menu.MM_showMenu(null,null,null,childMenu.layers[0]); childMenu.zIndex =3D l.parentLayer.zIndex +1; childMenu.top =3D l.Menu.menuLayer.top + l.Menu.submenuYOffset; if( l.Menu.vertical ) { if( l.Menu.submenuRelativeToItem ) childMenu.top +=3D l.top + = l.parentLayer.top; childMenu.left =3D l.parentLayer.left + l.parentLayer.clip.width - = (2*l.Menu.menuBorder) + l.Menu.menuLayer.left + l.Menu.submenuXOffset; } else { childMenu.top +=3D l.top + l.parentLayer.top;=09 if( l.Menu.submenuRelativeToItem ) childMenu.left =3D = l.Menu.menuLayer.left + l.left + l.clip.width + (2*l.Menu.menuBorder) + = l.Menu.submenuXOffset; else childMenu.left =3D l.parentLayer.left + = l.parentLayer.clip.width - (2*l.Menu.menuBorder) + l.Menu.menuLayer.left = + l.Menu.submenuXOffset; } if( childMenu.left < l.Menu.container.clip.left ) = l.Menu.container.clip.left =3D childMenu.left; var w =3D = childMenu.clip.width+childMenu.left-l.Menu.container.clip.left; if (w > l.Menu.container.clip.width) l.Menu.container.clip.width =3D = w; var h =3D = childMenu.clip.height+childMenu.top-l.Menu.container.clip.top; if (h > l.Menu.container.clip.height) l.Menu.container.clip.height = =3D h; l.document.layers[1].zIndex =3D 0; childMenu.visibility =3D "inherit"; } else if (FIND("menuItem0")) { childMenu =3D FIND(l.childMenu); var menuLayer =3D FIND(l.Menu.menuLayer); var s =3D childMenu.style; s.zIndex =3D menuLayer.style.zIndex+1; if (document.all || window.mmIsOpera) { s.pixelTop =3D menuLayer.style.pixelTop + l.Menu.submenuYOffset; if( l.Menu.vertical ) { if( l.Menu.submenuRelativeToItem ) s.pixelTop +=3D = l.style.pixelTop; s.pixelLeft =3D l.style.pixelWidth + menuLayer.style.pixelLeft + = l.Menu.submenuXOffset; s.left =3D s.pixelLeft + 'px'; } else { s.pixelTop +=3D l.style.pixelTop; if( l.Menu.submenuRelativeToItem ) s.pixelLeft =3D = menuLayer.style.pixelLeft + l.style.pixelLeft + l.style.pixelWidth + = (2*l.Menu.menuBorder) + l.Menu.submenuXOffset; else s.pixelLeft =3D = (menuLayer.style.pixelWidth-4*l.Menu.menuBorder) + = menuLayer.style.pixelLeft + l.Menu.submenuXOffset; s.left =3D s.pixelLeft + 'px'; } } else { var top =3D parseInt(menuLayer.style.top) + l.Menu.submenuYOffset; var left =3D 0; if( l.Menu.vertical ) { if( l.Menu.submenuRelativeToItem ) top +=3D parseInt(l.style.top); left =3D (parseInt(menuLayer.style.width)-4*l.Menu.menuBorder) + = parseInt(menuLayer.style.left) + l.Menu.submenuXOffset; } else { top +=3D parseInt(l.style.top); if( l.Menu.submenuRelativeToItem ) left =3D = parseInt(menuLayer.style.left) + parseInt(l.style.left) + = parseInt(l.style.width) + (2*l.Menu.menuBorder) + l.Menu.submenuXOffset; else left =3D (parseInt(menuLayer.style.width)-4*l.Menu.menuBorder) = + parseInt(menuLayer.style.left) + l.Menu.submenuXOffset; } s.top =3D top + 'px'; s.left =3D left + 'px'; } childMenu.style.visibility =3D "inherit"; } else return; window.activeMenus[window.activeMenus.length] =3D childMenu; } } function hideActiveMenus() { if (!window.activeMenus) return; for (var i=3D0; i < window.activeMenus.length; i++) { if (!activeMenus[i]) continue; if (activeMenus[i].visibility && activeMenus[i].Menu && = !window.mmIsOpera) { activeMenus[i].visibility =3D "hidden"; activeMenus[i].Menu.container.visibility =3D "hidden"; activeMenus[i].Menu.container.clip.left =3D 0; } else if (activeMenus[i].style) { var s =3D activeMenus[i].style; s.visibility =3D "hidden"; s.left =3D '-200px'; s.top =3D '-200px'; } } if (window.ActiveMenuItem) hideMenu(false, false); window.activeMenus.length =3D 0; } function moveXbySlicePos (x, img) {=20 if (!document.layers) { var onWindows =3D navigator.platform ? navigator.platform =3D=3D = "Win32" : false; var macIE45 =3D document.all && !onWindows && getExplorerVersion() = =3D=3D 4.5; var par =3D img; var lastOffset =3D 0; while(par){ if( par.leftMargin && ! onWindows ) x +=3D parseInt(par.leftMargin); if( (par.offsetLeft !=3D lastOffset) && par.offsetLeft ) x +=3D = parseInt(par.offsetLeft); if( par.offsetLeft !=3D 0 ) lastOffset =3D par.offsetLeft; par =3D macIE45 ? par.parentElement : par.offsetParent; } } else if (img.x) x +=3D img.x; return x; } function moveYbySlicePos (y, img) { if(!document.layers) { var onWindows =3D navigator.platform ? navigator.platform =3D=3D = "Win32" : false; var macIE45 =3D document.all && !onWindows && getExplorerVersion() = =3D=3D 4.5; var par =3D img; var lastOffset =3D 0; while(par){ if( par.topMargin && !onWindows ) y +=3D parseInt(par.topMargin); if( (par.offsetTop !=3D lastOffset) && par.offsetTop ) y +=3D = parseInt(par.offsetTop); if( par.offsetTop !=3D 0 ) lastOffset =3D par.offsetTop; par =3D macIE45 ? par.parentElement : par.offsetParent; } =09 } else if (img.y >=3D 0) y +=3D img.y; return y; } ------=_NextPart_000_0000_01C772E5.64B18020--